Indicated that minocycline could facilitate the extinction and attenuate the reinstatement Morphine CPP and also, attenuated the priming-induced reinstatement. Injection of minocycline during the extinction period blocked the maintenance of Morphine could reinstate the extinguished morphine-induced CPP. The morphine-induced CPP lasted for sevenĭays after cessation of morphine treatment. Injected 1 day after the final extinction day. To induce the reinstatement, a priming dose of morphine (1mg/kg) was The animals were tested for conditioning score 60 min after each Given daily bilateral intra-NAc injections of either minocycline (1, 5 and 10µg/ 0.5µl) or Following the acquisition of the CPP, the rats were Conditioned place preference (CPP) was induced by subcutaneous injection To determine whether minocycline could attenuate the maintenance and reinstatement of Such as minocycline can modulate the drug abuse effects. Glial activation has been linked with the drug abuse, and the glia modulators Relapse to drug is one of the most difficult clinical problems in treatingĪddiction. Downloaded from by San Diego (UCSD) on 08/31/15 Neuroscience Research Center, Shahid Beheshti University of Medical SciencesĮmail: J. Running title: Minocycline blocked maintenance and reinstatement of morphine Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, It may differ from the final official version of record.Īdministration of the glial cell modulator, minocycline, in the nucleus accumbensĪttenuated the maintenance and reinstatement of morphine- seeking behavior This Just-IN manuscript is the accepted manuscript prior to copy editing and page composition. Downloaded from by San Diego (UCSD) on 08/31/15įor personal use only.
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